A polygenic p factor for major psychiatric disorders
نویسندگان
چکیده
منابع مشابه
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, an...
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Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispani...
متن کاملTitle: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Recent large-scale studies have identified multiple genetic risk factors for mental illness and indicate a complex, polygenic, and pleiotropic genetic architecture for neuropsychiatric disease. However, little is known about how genetic variants yield brain dysfunction or pathology. We use transcriptomic profiling as an unbiased, quantitative readout of molecular phenotypes across 5 major psych...
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Reading the Perspective paper by Boyle, Li, and Pritchard entitled “An expanding view of complex traits: from polygenic to omnigenic” , I was torn initially between feelings of doubt and accord. Under a very provocative title, the authors present an excellent integrational analysis of current knowledge, and summarize in clear words what many scholars in the field would ultimately concur with. P...
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Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2018
ISSN: 2158-3188
DOI: 10.1038/s41398-018-0217-4